Phase 1 · Understand the Body — Why the disease behaves the way it does.
The One-Line Truth
The whole disease in one chain
Everything on this page exists to explain this chain.
A city blackout — burning the furniture
Glucose is fuel arriving by truck, and insulin is the delivery driver with the only key to every front door — without the driver, fuel piles up in the streets (blood) while every home (cell) goes cold. Desperate, the homes start burning furniture to stay warm: that's fat breaking down, and the thick acidic smoke that fills the streets is ketones souring the blood. The city tries to hose the piled-up fuel into the sewers — that's the kidneys flushing glucose into urine — but the hoses drag out the city's water and salts with it, which is why the patient is liters dry. Every treatment maps back: refill the water mains first (IV fluids), then send in new drivers (insulin drip) so the homes stop burning furniture and the smoke clears.
ADA Standards of Care 2024 · ISPAD DKA Consensus 2022 · ADA Hyperglycemic Crises (Diabetes Care) · UpToDate: DKA & HHS in Adults · reviewed 2026-02-28